Nitric Oxide Synthase(NOS) 억제제가 흰주에서 MK-801 유발행동에 미치는 효과

Effects of Nitric Oxide Synthase (NOS) Inhibitor on MK-801-elicited Behaviors in Rats

Objective: The aim of the present study was to investigate the effects of nitric oxide synthase (NOS) inhibitor on MK-801~liciled behaviors in rats in an attempt to elucidate the participation of NO in the pathophysiology of schizophrenia and to identify the possibility of NOS inhibitor's antipsychotic property. Methods: Male Sprague. Dawley rats, weighing 250-3OOg, were given MK-801 in order to know behavioral changes induced by MK-801. Next time, animals were pretreated with Na)-nitro-L-arginine (L-NA) as a NOS inhibitor and haloperidol before administration of MK-801, respectively. Separate behavioral rating scales were introduced for quantifying MK801-induced locomotor activity, stereotyped behaviors and ataxia in order that these behaviors might be assessed independently. Animals were observed for 30 seconds and scored once every 10min. during a period of 1 hour. Results: 1) Locomotor activity and stereotyped behavior were significantly increased by MK-801 in rats. 2) Locomotor activity and stereotyped behavior were significantly diminished by pretreatment with haloperidol 3) Locomotor activity and stereotyped behavior were also significantly diminished by pretreatment with L-NA. Conclusions: These findings suggest that NO may, in part, mediate behavioral changes induced by MK-80I, and that inhibitors of NOS may have antipsychotic action.