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Clinical Characteristics and Short-term Treatment Response in Patients with Obsessive-Compulsive Disorder

Objective : The aim of this study was to describe and evaluate the clinical data and short-term treatment response in patients with obsessive-compulsive disorder (OCD) based on an outpatient setting. Methods: A group of patients with OCD underwent mean 12.weeks treatment with selective serotonin reuptake inhibitors. The patients were divided into two groups according to treatment response, defined as a reduction of the Yale-Brown Obsessive Compulsive Scale total score >35% and COI of 1 or 2. Results, : I) Among the 249 patients, 24.1 % had checking type and 23.7% washing type. Among these two types, 31.9% had mood disorder, 15.0% had anxiety disorder and 24.5% personality disorder as co-morbidity. One hundred fourteen patients (45.8%) responded 10 the treatment and 135 (54.2%) did not The responders decreased Y-BOCS scores from 27.9±7.2 at baseline to 21.3±6.4 and 19.3±3.8 at post-treatment 8 and 12 weeks, respectively (repeated measure ANOYA, p=0.039). There were no differences among the treatment responses to serotonin reuptake inhibitors. Conclusion: About half of the OCD patients showed a response to pharmacologica1 treatment using SSRI in the outpatient clinic setting for 12 weeks. Long-term and contrast studies of OCD may elucidate further clinical aspects of this disorder in the future. (Korean J Psychopharmacol 2003;14(3):206-214)