주의력결핍-과잉행동장애에서 환자군과 가족군간의 Dopamine Transporter Gene에 관한 유전자 다형성 반복 대립유전자의 빈도

Dopamine Transporter Gene Polymorphism Association between ADHD Parients and the Parents Group

Objectives: Attention deficity hyperactive disorder is known to be a disease with a high genetic trait. Recently the relationship between alleles frequency distribution and ADHD has been actively researched. In Korea, the relationship between the genetic type and alleles for dopamine transporter gene has been studied in ADHD patients. Methods: Thirty five patients diagnosed with ADHD according to the DSM-IV diagnostic criteria were selected for study. The diagnosis and clinical features were confirmed by korean version Child behavior check list, korean version Conner's parent rating scale, Attention deficit Diagnostic System, korean version Spielberger state-trait anxiety scale etc. For the control group, the parents of patients were chosen. Blood samples were taken from the 105 subjects. DNA was extracted from blood lymphocytes, PCR was performed for dopamine transporter gene. Results and Conclusion: In comparing the ADHD transmitted group and the not transmitted group, significant difference was seen between the DATI genetic type and alleles distribution. As a result, it is viewed that there is relationship between ADHD and the dopamine transporter gene. Follow up studies with larger patient or pure subgroups are expected. (Korean J Psychopharmacol 2003;14(4):347-353)