주의력결핍 과잉행동 장애 아동에서 Methylphenidate 치료반응 예측인자로서의 기저신경절 Dopamine Transporter Density-[123I]IPT SPECT 연구

Dopamine Transporter Density of the Basal Ganglia as a Predictor of Methylphenidate Response in Children with Attention Deficit Hyperactivity Disorder-A[123I]IPT SPECT Study

Objective: Dopamine transporter is a key regulator of dopamine neurotransmission and is also the primary target of methylphenidate. This study tested the hypothesis that dopamine transporter (DAT) density in basal ganglia is a predictor of favorable methylphenidate (MP) treatment response, Methods: 15 drug-naive boys with ADHD were included in this study (8 children: treatment responder, 7 children: treatment non responder). They were assessed with psychiatric interview, KEDI- WISC, K-ARS, ADS and CBCL. After then, they were performed [123I]IPT SPECT. They were evaluated about treatment response after treatment with methylphenidate during 8 weeks. SPECT data reconstructed for the assessment of specific/nonspecific DAT binding ratio of the basal ganglia were compared between treatment responders and nonresponders. Results: There were not significant differences in dopamine transporter density in basal ganglia between the two groups. Conclusion: This finding suggests that dopamine transporter density does not mediate the MP treatment response in a direct way. (Korean J Psychopharmacol 2003:14(4):377-386)