[원저] 초발 정신분열증 환자세어 Olanzapine 사용 전후 [123I]-IPT-SPECT로 측정한 선조체 도파민 운반체 변화와 정신병리의 관계

Correlation between Psychopathology and Dopamine Transporter Density in Striatum before Taking Olanzapine Assessed with IPT-SPECT in First Episode Schizophrenia

Objective : Using [123I] IPT-SPECT. we compared between the dopamine transporter (DAT) density of the basal ganglia in first-episode. patients with schizophrenia and DAT density in normal control subjects. We investigated the change between DAT density before and after taking olanzapine during 4weeks in patients with schizophrenia. We studied correlations between the clinical symptoms of schizophrenia and DAT density. Methods : Ten patients with schizophrenia and ten healthy control subjects were included in this study. Brief Psychiatric Rating Scale (BPRS) and Montgomery-Asberg Depression Rating Scale (MADRS) were obtained before and after 4week treatment with olanzapine in schizophrenic group. Nuclear imaging using [123I] IPT-SPECT was obtained in normal control subjects and schizophrenic group before taking olanzapine. After 4-week treatment with olanzapine. Nuclear imaging was obtained in schizophrenic group. Results : There is significant negative correlation between BPRS total score. withdrawal subscale score after treatment and DAT density before treatment. There is significant positive corrclation between the age of onset and DAT density after treatment and there is significant negative correlation between the duration of illness and DAT density after treatment. Conclusion: The data of this study suggest that DAT density in basal ganglia in patients with schizophrenia would be a predicting factor in treatment response.