[원저] 일 대학병원 신경정신과 외래에서의 비전형 항정신병약물과 선택적 세로토닌 재흡수 차단제의 병합처방 빈도

Frequencies of Combination Treatment of Atypical Antipsychoties and Selective Sertonin Outpatient Unit

Objective : The introduction of new psychiatric medications with better efficacy and tolerance seems to increase the frequencies of co-prescriptions of various psychotropic agents. We investigated the frequencies of the combined treatments of atypical anti psychotics and selective serotonin reuptake inhibitors (SSRIs) that are supposed to be common in clinical practice. Methods : Data on 2783 outpatients from March I, 2002 through June 31, 2002 in Seoul National University Hospital were collected. The number of cases with a co-prescription of atypical antipsychotics with SSRIs were counted and compared by diagnoses. The relations of diagnosis and age to the combined treatment were explored. Results: 499 ( 17.4%) patients took co-prescriptions of antipsychotics with antidepressants. and 393 (13.7%) patients those of atypical antipschotics with SSRIs. Patients with obsessive compulsive disorder and schizophrenia took the combinations of atypical anti psychotics and SSRIs more frequently than patients with other diagnoses. as 4 1.6% and 20.8%. respectively. Controlling for diagnostic categories. age was significantly correlated with the presence of those co-prescriptions. Conclusion: The findings of the current study reflect evidence-based prescriptions in an educating hospital and provide basic data for further pharmaco-epidemiological studies. The co-prescription of atypical antipsychotic agents with SSRIs seems to occur only in proper indications. under the consideration of the risk of drug-drug interactions and adverse effects