[증례] 양극성 정동장애 환자에서 Valproate 사용 후 발생한 가역성 파킨슨증 1예

A Case of Reversible Parkinsonism Induced by Valproate in a Patient with Bipolar Disorder

The author reports a case of reversible parkinsonism induced by valproate. The patient (61 years old male) with bipolar disorder developed typical parkinsonism from the initial period of valproate administration (dose: 1500 mg. serum level: 108.1 ug/mL. Parkinsonism was partially relieved by coadministration of anticholinergic agent and disappeared rapidly after discontinuation of valproate. In psychiatric conditions such as bipolar disorder or other psychotic illness. the possibility that the extrapyramidal sympoms be induced by valproate should be taken into careful consideration. In that case. carbamazepine can be recommended as a substitute medication.