[원저] 비정형 항정신병약물이 혈중 당질 및 지질에 미치는 영향과 세로토닌 수송체 유전자 다형성과의 연관성

Association between Serotonin Transporter Polumorphism and the Effect of Atypical Antipsychoties on Serum Glueose and Lipids

Objective : The author investigated the association between the genotype distribution of 5-HITLPR and the effects of atypical anti psychotics on serum glucose and lipids in schizophrenic patients. Methods: Study subjects were 66 schizophrenic patients taking atypical antipsychotics (risperidone, olanzapine, cIozapine, quetiapine, zotepine). The control group consisted of 82 schizophrenic patients taking typical antipsychotics (haloperidol). All subjects were medicated for at least 12 weeks. The author examined serum fasting blood sugar (FBS), HbA lc, total cholesterol, triglyceride, and the genotype distribution of 5-HITLPR in all subjects. The presence of the 5HITLPR gene was determined by using polymerase chain reaction of genomic DNA with primers flanking the promoter regions of the 5-HTT gene. Between group comparisons of the genotype distribution and the effects of antipsychotics on the serum glucose and lipid levels were performed by using score test for t-test, one way ANOYA, and chi-square test. Results : There was a significant increase in FBS level in all patients taking atypical antipsychotics except for those treated with risperidone. However, there was no statistically significant correiation between 5-HITLPR genotype distribution and the effect of atypical antipsychotics on FBS, HbAl c, total cholesterol, and triglyceride serum levels in schizophrenic patients. Conclusion: These results suggest that 5-HITLPR polymorphism has no significant association with the effect of atypical antipsychotics on serum glucose and lipids in Korean schizophrenic patients.