[원저] 만성 정신분열병 환자에서 비정형적 항정신병 약물 단독요법과 Sodium Valproate 병용요법 시 혈당 및 콜레스테롤 수치의 변화

Changes in Glueose and Cholesterol Level in Schizophrenie Patients Treated with Atypical Antopsychoties or with Valproate Combination

Objective : The association of obesity, diabetes mellitus, drug compliance, and body image with use of antipsychotic medication has been documented in many studies. We aimed to assess the effects of antipsychotics and sodium valproate combination therapy on glucose, cholesterol level and weight in schizophrenic patients. Methods : Chronic schizophrenic patients were grouped according to drug combination: risperidone, olanzapine, haloperidol, risperidone+ valproic acid (VP), olanzapine+ VP, haloperidol + VP. Planned assessment of included glucose and cholesterol, which were collected at baseline and at the end of the 12 weeks later. Results: There were significantly increased glucose and cholesterol level. in olanzapine+ VP group, but not in rispcridone group. Cholesterol levels were not increased at the end of 12 weeks for haloperidol and rispcridone group. Glucose and cholesterol levels had no significant association with weight gain. Conclusion: Changes in glucose and cholesterol level. weight, and body mass index associated with anti psychotics including sodium valproate combination were reported in our report. In the future, we need follow up study and various studies about other combination drug and metabolic symptoms.