송사리에 있어서 사염화탄소의 독성에 관한 연구: LC50값 및 조직병리학적 변화

A Study on the Toxicity of Carbon Tetrachloride in Oryzias latipes LC50 Values and Effect on Histopathological Alterations

The purpuses of this study were 10 establish the toxicological indices(LD50 values and histopathological changes) of carbon tetrachloride(CCl:) in Oryzias latipes. The results are summarized as follows: 1. The LD50 value of carbon tetrachloride in Oryzias latipes was 41.6mg/l at 48 hours after exposure, and confidence range of 95% were 37.2~48.8mg/l. The lethality were increased in proportion to exposure concentration of carbon tertachloride and to lapse of exposure time. 2. Vacuolizalion incidences of liver cell in control. 10.6, 18.0, 30.5, 51.9 and 88.2mg/l concentration groups were 1. 3. 3, 5. 5. and 5 of 5 in each group, respectiveIy. lncidences fatty degeneration were O. 2. 3. 5. 5. and 5. respectively and glycogen accumulation incidences were 4 and 5 in control and all exposure groups, respectively. In conclusiouns, the toxicity of carbon tertachloride in Oryzias latipes appeared at nearly 41.6mg/l concentration and carbon tetrachloride-induced phases of histopathological alterations of liver cell were observed in relatively low concentration.