수산동물에서의 nitric oxide(NO)의 생리적 및 병리적 역할과 미래의 연구과제

Pathological and Physiological Role of Nitric Oxide (NO) in Aquatic Animals and Future Research Direction

A tremendous amount of data has been accumulated with regard to the pathological and physiological role of the highly elusive endogenous substance nitric oxide (NO). Despite the extensive investigation on NO by numerous researchers in mammals including humans, the information on the existence and signi ficance of NO in aquatic animals is quite rare. In view of the fact that ~O production is likely to be stimulated with Gram negative pathogenic bacteria in certain fishes, its participation in the pathological process of aquatic animal diseases should be clari fied. The aim of this article is to review the known roles of NO in aquatic animals, and to suggest future research directions related to its pathophysiological role.