Risperidone Beyond Psychoses

Risperidone Beyond Psychoses

The authors have compiled the available references on the use of risperidone in 'non -psychotic conditions', not including schizophrenia and bipolar disorders. In addition, information was gathered on the mechanism of action of risperidone in these diverse disorders. Atypical anti psychotics are known to have fewer adverse effects seen with conventional anti psychotics, such as tardive dyskinesia (TD), reuroleptic malignant syndrome (NMS), and cognitive disturbances, and they possess a 'broad range of therapeutic efficacy.' The broad psychotropic effects, apart from the anti psychotic action, of risperidone are attributed to their particular pharmacological properties, which differ greatly from those of conventional anti psychotlcs. Risperidone has a greater affinity for the dopamine 02 receptor than for the 01 receptor, but its 02/5-HT2 affinity ratio is low. This fixed 02/5HT2 ratio may bring about significantly different clinical effects depending on the dosage. The dose-dependent pharmacologic properties of risperidone, in the form of the effects of blocking the 5-HT2 receptors, which are observed at lower doses, and the effects of 02 blockade, which are manifested progressively with increasing dosage, may be the basis of the efficacy of risperidone In non-psychotic conditions at lower doses than in psychoses. The authors have also ascertained that risperidone may be of efficacy in the treatment of non-psychotic conditions other than the major psychoses The authors consider the different dosages depending on the diagnoses to be reflective of differences in the etiopatho physiology between the conditions. In addition, the authors have noted that risperidone, at low doses, shows efficacy in the treatment of a wide variety of disorders other than psychotic disorders, Including mood disorders (manic and depressive episodes), obsessive symptoms, and movement disorders. This also demonstrates the greater range of therapeutic efficacy of risperidone othe' than conventional anti psychotics Despite the fact that risperidone possesses such various therapetic actions, the first-line drugs In the treatment of non-psychotic conditions are and should be non-anti psychotic psychotroplcs; rispendone is still an anti psychotic drug, with all the entailing characteristics, and it IS not completely free of the side effects common in conventional antipsychotics, such as EPS. Wisdom IS called for in the appropriate application of risperidone in the treatment regimen of suitable patients following treatment with other non-antipsychotic psychotropics It seems to review all non-psychotic psychiatric disorders via the clinical applications of risperidone. Through expansion of the Indications for risperidone, further insight will be gained on its previously unknown psychotropic effects and the etiopathophysiology of the indicated conditions.