정신분열병 도파민 가설의 과거, 현재 그리고 미래

Past, Present and Future of Dopamine Hypothesis for Schizophrenia

Many neurotransmitters other than dopamine, such as serotonin, glutamate, etc, have been implicated in the pathophysiology of schizophrenia. The atypicality of new antipsychotics has been attributed to the relatively more potent 5-HT2A receptor antagonism compared to D2 receptor blocking action. However, dopamine still seems to be a cornerstone In terns of the pathophysiology of schizophrenia and mode of action of antipsycthotics. Therefore, we reviewed all the relevant papers about the dopamine hypotheses for schizophrenia and reclassified into 3 categories 1) Regional classification of dopamine hypothesis , 2) Dopamine gating (filtering) hypothesis, and 3) Time-course classification of dopamine hypotheis How they are developed and the Implications of each hypowill be described in detail In the future, dopamine hypothesis at molecular or cellular levels will be investigated more extensively though Its current status is very primitive. (Korean J Psychopharmacol 200;15(4):393-400)