공황장애 환자에서 파록세틴 약물 치료가 바이오피드백 측정 변수들에 미치는 영향

Effect of Pharmacotherapy with Paroxetine on Biofeedback Measurement Variables in Panic Disorder Patients

Objective There have been much effort to find reliable indicators predicting treatment response in pamc disorder This study aimed to find the effect of pharmacotherapy on biofeedback measurement variables in panic disorder patients. Method' We recruited 38 panic disorder patients (M˙25, F 13) in the Samsung Medical Center, who were diagnosed by the ADIS-IV (Anxiety Disorder Interview Schedule-IV), and 33 normal control subjects (M˙21 F˙12). Panic patients were treated with paroxetine for 3 months All subjects were assessed on forearm and frontal electromyography (EMG) , electrodermal response (EDR), and skin temperature in baseline, stress, recovery phases using the Procomp & Biograph biofeedback Instrument. Psychological measures such as Hamilton anxiety rating scale (HAM-A), Hamilton depression rating scale (HAM-D), Beck depression inventory (BDI) , Spielberger state-trait anxiety Inventory (STAI-S, STAI-T), and Anxiety sensitivity index (ASI) were also assessed All measurements were performed at the beginning of the study and after 3 months of paroxetine treatment Result Panic patients had significantly higher scores on psychological measures such as HAM-A, HAM-D, BDl, STAI-S, STAI-T, and ASI (all p values<0.001) before treatment After 3months of treatment, panic patients showed significant improvement on baseline EDR (z=2.824, p=0.005), stress EDR (z=-2.691, p=0.007), and recovery EDR (z=-3416, p=0.001) They also showed significant Improvement on HAM.A, HAM-D, BDI, STAI-S, STAI- T, and ASI (all p values<0.001) after treatment Conclusion Electrodermal response, one of the biofeedback measurement variables, was suggested to be the possible indicator predicting treatment response to panic disorder (Korean J Psychopharmacol 2004;15(4):468-473)