주요 우울장애 환자에서 Mirtazapine 투여 후 발생한 하지 불안 증후군 1예

A Case of Restless Leg Syndrome Induced by Mirtazapine in a Patient with Major Depressive Disorder

Mirtazapine is a novel antidepressant and has a unique dual action profile, combining the enhancement of the noradrenergic neurotransmitter system with specific actions on particular serotonergic receptor subtypes The authors report a case of restless leg syndrome induced by nurtazapine The patient (46 years old male) with major depressive disorder developed typical restless leg syndrome from the initial period of administration of mirtazapine. Restless leg syndrome was not relieved by reduction of mirtazapine and disappeared rapidly after discontinuation of nurtazapine. The major difference of the case from previously reported cases is the onset time of symptoms We may consider that nurtazapine can induce dopaminergic side effect like a restless leg syndrome promptly as Its fast-acting antidepressant effect (Korean J Psychopharmacol 2004;15(4):488-491)