소량의 Mirtazapine 1회 복용 직후 발생한 하지 불편 증후군 2예

A Single Low Dose of Mirtazapine can Induce Restless Legs Syndrome：Report of Two Cases

The two cases of patients with restless legs syndrome induced by a single oral dose of mirtazapine 7.5 mg were reported. Two elderly women were administrated with 7.5 mg of mirtazapine for controlling depression and insomnia. Approximately 1-2 hours after taking the medicine, they experienced unpleasant restless feelings in their arms and legs. They had to rub or move the extremities for alleviating the symptoms. They could not fall asleep due to the severe paresthesia and restlessness until they took benzodiazepines. The next day, the symptoms began to disappear. These symptoms have not developed again after they refused taking mirtazapine. These two cases suggest that a single low dose of mirtazapine can induce restless legs syndrome.