Cytochrome P450 효소군의 유전자형 분석이 항우울제 선택에 도움을 준 주요우울장애 환자의 사례 연구

Selection of an Antidepressant Based on the Genotypes of Cytochrome P450 Enzymes Genes in a Patient with Major Depressive Disorder

We present a case of 34-year-old female patient with major depressive disorder who had decreased metabolic activity of CYP2D6. Low dosage regimen of mirtazapine & paroxetine led to unexpectedly severe adverse effects and noncompliance in this case with genotype CYP2D6 ^*1/^*5. Antidepressant change to imipramine with consideration of the genotyping resulted with tolerable adverse effects and remission of depression. This case suggests the clinical usefulness of pharmacogenetic testing in individualized antidepressant treatments.

ABSTRACT

서 론

증 례

고 찰

참고문헌

(0)

(0) 팝업 열기

팝업 닫기

(0)

(0)