5-HT₁<SUB>A</SUB>수용체의 기능과 약물치료

The Function of 5-HT₁<SUB>A</SUB> Receptor and Pharmacotherapy

&nbsp;&nbsp;5-HT₁<SUB>A</SUB> receptor is implicated in the pathogenesis and the therapeutic mechanism of various psychiatric disorders. Especially, the mechanism of action of selective serotonin reuptake inhibitors (SSRIs) was hypothesized that 5-HT₁<SUB>A</SUB> autoreceptor desensitization plays an important role in the treatment of depression and anxiety. 5-HT₁<SUB>A</SUB> receptor stimulation may also mediate the neurogenesis of prefrontal cortex and hippocampus. 5-HT₁<SUB>A</SUB> agonism has an important meaning in the treatment of schizophrenia. Most atyptical antipsychotics have the property of 5-HT₁<SUB>A</SUB> antagonist, and some have that of 5-HT₁<SUB>A</SUB> agonist. In the various regions of brain, 5-HT₁<SUB>A</SUB> and 5-HT₁<SUB>A</SUB> have the functionally antagonistic properties. Recently, 5-HT₁<SUB>A</SUB> receptor-related agents have been investigated in the treatment of acute ischemic stroke and Alzheimer"s disease. Therefore, the further understanding about the 5-HT₁<SUB>A</SUB> receptors in the brain functions will provide the development of future drugs and the advancement of psychopharmacology.