한국인 공황장애 환자의 진단과 약물치료 반응에서 Cholecystokinin 프로모터 유전자 -36C＞T 다형성과의 연관성

Association Study of the -36C＞T Polymorphism in the Cholecystokinin Promoter Gene with the Diagnosis and the Response of Pharmacotherapy in Korean Patients with Panic Disorder

  Objective：This study aimed to test the possible association between cholecystokinin (CCK) promoter gene and panic disorder. Methods：267 patients with panic disorder and 82 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-based method. Results：Genotype and allele distribution of CCK promoter -36C＞T polymorphism patients with panic disorder was not significantly different from those of the controls. In addition, after excluding panic disorder patients with major depressive disorder, we did not find out the association of CCK-36C＞T with the panic disorder without comorbidities. Conclusion：This study suggested that the CCK promoter -36C＞T polymorphism may have not a potential role for susceptibility to panic disorder in the Korean population. Thus calls for consecutive studies in order to pile up the data with larger different ethnic background. (Korean J Psychopharmacol 2006;17(2):212-218)