운동과 EPO(Erythropoietin)와의 관계

Relative in Exercise and EPO(Erythropoietin)

&nbsp;&nbsp;Erythropoietin is produced mainly in the kidney and regulates erythrocyte production. It binds to a cell surface receptor and leads to intracellular activation of several kinase pathways. EPO is a hypoxia-induced hormone that is essential for normal erythropoiesis. The production of recombinant human erythropoietin has revolutionized the treatment of anemia associated with chronic renal failure and chemotherapy. EPO has similar structure and signaling mechanisms to the family of type I cytokines and is markedly induced by hypoxia. EPO is synthesize by peritubular cells in the cortex-medullary border of the kidney and in the liver during fetal and neonatal development. A variety of other tissues have been reported to express erythropoietin including bore marrow macrophages, trophoblasts, breast glands, and astrocytes.<BR>&nbsp;&nbsp;Therefore, This study was invested relative in exercise and EPO, we had a conclusion as follows; 1) EPO is useful on polycythemia in test. 2) In patients with chronic renal insufficiency, r-HuEPO has also been shown to improve exercise capacity. 3) EPO has similar structure type I cytokines and induced by hypoxia.