운동과 2,3-DPG(diphosphoglycerate)와의 관계

Relative in Exercise and 2,3-DPG(diphosphoglycerate)

  2,3-DPG is synthesized from glycolytic intermediates by a pathway known as Rapoport-Luebering shunt. The production of 2,3-DPG depends on the relative amounts of its precursor, 1,3-DPG going into Rapoport-Leubering pathway and into the ATP-forming glycolytic pathway. Its concentration also depends on the rate of hydrolysis of 2,3-DPG The most important function of 2,3-DPG is its effect on the oxygen affinity of Hb. Normal Hb in deoxygenated state can bind 2,3-DPG in a molar ration of 1:1 which results in reduced oxygen affinity of Hb and enhanced oxygen delivery to tissues. In oxygenated state the ability of Hb to bind 2,3-DPG is decreased and most DPG is in free state. As the result the affinity of Hb to oxygen is increased and it binds more of oxygen. Changes in 2,3-DPG levels have important role in adaptation to hypoxia. In anemia and certain hypoximic conditions, 2,3-DPG level in erythrocytes increase and oxygen affinity of Hb is reduced resulting in improved delivery of oxygen to tissues. This study was invested relative in exercise and 2,3-DPG we had a conclusion as follows; 2,3-DPG was increased in anemia, congestive heart failure, heart disease, hyperthyroidism but it was decreased in diabetic. Hypoxia was decreased and extremely exercise was increased.