수면 무호흡증 환자에서 Angiotensin converting enzyme, Angiotensinogen M235T의 유전적 다형성

Polymorphism of Angiotensin converting enzyme, Angiotensinogen M235T in patient with sleep apnea syndrome

  Obstructive sleep apnea(OSA) occcurs when tissues in the upper airway collapse during sleep, and is accompanied by hypoxemia and EDS(excessive daytime sleepiness). Also OSA is related to hypertension and cardio-vascular disease. According to recent study, OSA possibility is estimated through partial gene"s predispoding factor. To study the correlation of OSA and angiotensin converting enzyme and angioten-sinogen genotype, this study examined genetic polymorphism of OSA patient and normal case using PCR and restriction enzyme digestion. We found significant differences between most sevene obstructive sleep apnea and normal control in the ACE genotypes. The freguency of genotypes in MSO was: DD : 15.5%, ID : 82.2%, Ⅱ : 2.2%(p＜0.05) The freguency of genotypes in Normal group(NO) was: DD : 8.5%, ID : 71.8%, Ⅱ : 19.7%. But there were no significant differences between obstructive sleep group and normal control in the AGT(M235T) genotypes. The freguency of genotypes in MSO was : MM : 8.9%, MT : 13.3%, TT : 77.8%. In normal group was: MM : 5.6%, MT : 25.4% TT : 69.0%. Our data suggest some effect between ACE polymorphism and OSA but no effect between AGT polymorphism and OSA.