한약재로부터 추출된 물질의 면역 효과

Effect of material isolated from chinese medicinal herb on immune system

&nbsp;&nbsp;This study is focused on clarifying the functional aspects of the extracts from Gleditsiae spina, which has been used as one of the favorite chinese medicinal herbs for a long time. To detect the possible effects of Gleditsiae spina extracts on the immune system of mice, macrophage lysosomal enzyme activity and anti-complementary activity were calculated in semi-vivo. Among different solvent extraction, hot water extract of Gleditsiae spina showed higher macrophage lysosomal enzyme activity and anti-complementary activity than others.<BR>&nbsp;&nbsp;During mass extraction, low molecular weight fraction was removed by using MtOH extraction of Gleditsiae spina. High molecular fweight raction was obtained by hot water extraction and the EtOH precipitation. Fraction GS-1, showing 212% macrophage lysosomal enzyme activity and 81.5% anti-complementary activity, consisted of 38.8% carbohydrate, 21.1% protein and 10.1% uronic acid. Besides no lethal toxicity was observed in GS-1.