노화와 항산화효소의 역할에 관한 고찰

Study on ageing and role of antioxidants

  In organisms, oxygen is essential but has a deleterious effects. Deleterious effects of oxygen is production of reactive oxygen species(ROS), for example superoxide radical(O₂？), hydrogen peroxide(H₂O₂), hydroxyl radical(OH.). But organisms produce antioxidants autonomically for recover the oxygen toxicity. Especially superoxide dismutase(SOD), catalase and glutathione peroxidase(GSH-PX) have a major roles against reactive oxygen species in organisms. Also reactive oxygen species induce many diseases. It is well understanding facts that ageing, cancer and arteriosclerosis occur by reactive oxygen species. Present antioxidants and reactive oxygen species were considered important in the field of biology, medicine, pharmacology, sitology, agriculture, toxicology, environment and many others. If we know the processes of production and mechanisms of reactive oxygen species, toxic effects of radicals will be reduce dramatically in living organisms. So understanding the mechanisms of response and processes of production is essential.