학습 및 기억에서의 5-HT<SUB>1A</SUB> 수용체의 역할

Role of 5-HT<SUB>1A</SUB> Receptors in Learning and Memory

  Growing evidence indicates that the serotonin system is important in learning and memory. In particular, several preclinical and clinical studies suggest that modulating the 5-HT<SUB>1A</SUB> receptor can influence learning and memory, and indeed, it has been observed that presynaptic 5-HT<SUB>1A</SUB> receptor agonists and postsynaptic 5-HT<SUB>1A</SUB> receptor antagonists tend to ameliorate the learning/memory impairment induced by various methods. In contrast, postsynaptic 5-HT<SUB>1A</SUB> receptor agonists tend to decrease the learning/memory function. These observations suggest the possibility that modulating neurotransmission mediated by the 5-HT<SUB>1A</SUB> receptor may be effective as a therapeutic strategy for enhancing learning and memory in various neuropsychiatric disorders. Unfortunately, there is no available discussion on the relationship between 5-HT<SUB>1A</SUB> receptor and learning/memory in Korea. This article reviews the clinical or preclinical literature on this issue.