한국인 비당뇨 성인에서 혈청 GGT와 대사증후군과의 관련성

Relationship between serum γ-glutamyltransferase and metabolic syndrome among Korean non-diabetic adults

Purpose: This study was conducted to investigate the association of γ-glutamyltransferase (GGT) with metabolic syndrome among non-diabetic adults. Methods: This study was conducted in a rural area, South Korea from August, 2003 to November, 2003. The study subjects were 1,023 sampled persons aged from 40 years and older (male 377, female 646). We analyzed the association between GGT with metabolic syndrome by multiple logistic regression analysis using SAS 9.1 version. Results: The prevalence of metabolic syndrome in this study was 28.8%. The prevalence of metabolic syndrome was increased by quartiles of serum GGT level (P for trend <0.05). The prevalence of metabolic alterations fitting the criteria of the metabolic syndrome by quartiles of serum GGT level were almost significantly increased except for the criterion of low high density lipoprotein (HDL) cholesterol with adjustment for age and alcohol intake. Among 5 components of metabolic syndrome, the criterion of high serum triglyceride was most powerfully associated with serum GGT level in both gender. Conclusions: This study shows that serum GGT level was significantly associated with metabolic syndrome even after excluding diabetic adults.