Anti-GQ1b 항체 양성을 보인 Mycoplasma pneumoniae 감염에 의한 Miller-Fisher 증후군 1례

A Case of Child with Miller Fisher Syndrome Diagnosed by Anti-GQ1b Antibody from Mycoplasma Pneumoniae

저자들은 전형적인 외안근 마비와 운동실조, 심부건반사 소실 증상을 보이고 항 GQ1b 항체가 양성으로 측정되면서 선행 감염원으로 Mycoplasma pneumoniae 항체가가 양성으로 증명된 8세 남아의 Miller-Fisher 증후군 1례를 경험하였기에 보고하는 바이다.

Miller Fisher syndrome, first reported by Miller Fisher in 1956, is characterized by a triad of external ophthalmoplegia, areflexia, and ataxia. Many features shared with Guillain-Barré syndrome; CSF usually shows elevated proteins and the syndrome is often is preceded by an infectious disorder. It is believed that the level of anti-GQ1b IgG antibody is elevated during an acute phase, increases and decreases rapidly during clinical recovery, that the level of anti-GQ1b IgG can be used as a diagnostic tool for Miller Fisher syndrome during an acute phase. We report an 8 year-old boy who showed typical clinical manifestations of Miller Fisher syndrome, with respiratory tract illness, associated with the seroconversion of Mycoplasma pneumoniae titers during the development of neurological symptom, with positive anti-GQ1b IgG.