조화운동불능을 동반하지 않은 Miller Fisher 증후군 2례

Two Cases of Miller Fisher Syndrome without Ataxia

저자들은 감염성 질환 후에 발생한 급성 외안근마비, 심부건반사 소실을 주소로 내원한 Miller Fisher 증후군이 의심되는 환아에서 항 GQ1b 항체를 측정하여 진단에 활용하여 항체 양성 환아 1례와 음성 환아 1례를 각각 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

A classic triad of acute external ophthalmoplegia, areflexia and ataxia characterizes Miller Fisher syndrome(MFS). Diagnosis is based on clinical findings and supported by two laboratory findings; CSF albuminocytological dissociation and serum anti-GQ1b IgG antibody testing. Anti-GQ1b antibody is a key factor in the pathogenesis of Miller Fisher syndrome and a useful marker in laboratory diagnosis. Here we report 2 cases with Miller Fisher syndrome without ataxia, whose major symptom was acute external ophthalmoplegia. Case 1 was associated with preceding Epstein-Barr virus infection and negative anti-GQ1b antibody. Case 2 was positive for the anti-GQ1b antibody. Both received intravenous immunoglobulin and fully recovered within 2 months after the onset of disease.