Lamotrigine에 의해 유발된 항경련제 과민증후군

Lamotrigine-induced Anticonvulsant Hypersensitivity Syndrome : Treatment with Steroid and Intravenous Immunoglobulin

저자들은 라모트리진으로 인한 발열, 피부발진, 호산구증 그리고 간침범을 동반한 항경련제 과민증후군을 경험하였고, 이를 스테로이드와 정맥 면역글로불린으로 치료하여 완치된 환아 1례를 경험하였기에 보고하는 바이다.

Lamotrgine is an antiepileptic drug that is effective for multiple types of seizure and has side-effects such as headache, nausea, dizziness, diplopia, ataxia, cutaneous lesions, and anticonvulsant hypersensitivity syndrome. Anticonvulsant hypersensitivity syndrome consists of the hallmark features of fever, rash, lymphadenopathy and internal organ involvement, induced by aromatic anticonvulsants, for example phenytoin, phenobarbital, carbamazepine, and lamotrigine. We report a case of 13-year-old girl who had a fever, generalized erythematous skin eruption, facial edema, eosinophilia, and elevated liver enzyme induced by lamotrigine and resolved with discontinuation of medication and intravenous steroid and immunoglobulin.