동일 열성질환에서 반복성 열성경련의 예방을 위한 Diazepam의 효과

Effect of short term diazepam prophylaxis in repeated febrile seizure during same febrile illness

The efficacy of short-term diazepam prophylaxis in repeated febrile seizures was evaluated in a prospective controlled study. A total 172 consecutive children admitted with their febrile seizure were participated in our study from May,1991 to June,1992. The children of control group were admitted with their febrile seizure from January,1987 to December,1990. Intravenous Diazepam(0.1mg/kg) is administered to patients with febrile seizures at admission. And oral Diazepam(0.5mg/kg/day) is administered at first hospitalization day. At second hospitalization day, consecutive oral Diazepam (0.6 mg/kg/day) is administered. The results were as follows: 1) The incidence of repeated febrile seizure was 8.1% in study group and 17.0%in control group. 2) In hospital, repeated febrile convulsion was 0.6% in study group and 4.3% in control group. 3) The repeat rate of febrile seizure with fever less than 39℃ was 6.3% in study group and 20.5% in control group. 4) The repeat rate of febrile seizure with serum sodium concentration under 135mEq/L was 10.9% in study group and 47.4% in control group. 5) There was no serious side effects of diazepam.