뇌량 부분 형성부전 환아의 임상적 고찰

Clinical Features of Partial Agenesis of Corpus Callosum

59 cases with partial agenesis of corpus callosum visited to Department of pediatrics. College of medicine, Yonsei university, from Jan.1980 to Dec.1993, were reviewed on the basis of clinical characteristics. The results were summarized as follows: the age distribution were 31 cases(52.5%) under 1year, 20 cases(33.8%) from 1 to 5 years, 8 cases(13.7%) from 6 to 15 years. Sex distribution revealed males to females to be 1:1.2. All cases shewed mental retardation, 30 cases(50.8%) with seizure, 8 cases(13.6%) with cerebral palsy, and the most common type of seizure was generalized tonic clonic seizure. 24 of 56 patients had abnormal perinatal history: 22% of them had perinatal asphyxia, 10%. low birth weight, 6.7%. prematurity. 48 patients had associated anomalies. among which craniofacial anomaly was the most common and 8 patients had cardiovascular. 8 patients, skeletal anomalies. We used Griffith developmental scale to assess the developmental status in 31 cases. None of the cases achieved the score above 85 for general intelligence quotient and 24 cases were below 55. EEG revealed most commonly asymmetricity between two hemispheres. some of them showed spikes and slow waves.