항우울제가 LETO쥐의 에너지 대사에 미치는 영향

The Effects of Antidepressants on the Energy Metabolism in LETO Rat

본 연구에서는 실험동물에서, 항우울제 투여 이후 발생하는 체중 및 식이 섭취량의 변화와 식이 효율을 비교하고, 혈액 및 세포 조직에서의 대사 관련 물질과의 연관성에 대해 확인하였다. 연구 결과 항우울제 투여 이후 식이 섭취량은 모든 약물 투여군에서 저하되었으며, 식이 효율은 fluoxetine 투여군에서 감소하였다. 실험동물에서 혈액 및 조직을 이용하여 진행한 연구에서 amitriptyline 투여군과 mirtazapine 투여군은 지방세포에서 PGC-1β, UCP-1, UCP-2, UCP3 mRNA의 발현이 유사한 결과를 보였으며, fluoxetine 투여군은 leptin과의 유의한 연관성이 나타났다. 이는 항우울제가 에너지 대사에 있어 항우울제의 기전에 따라 차이를 나타낼 가능성을 제시한다.

Objectives：A diverse range of adverse effects has been linked to the application of antidepressants for the treatment of depressive disorder. Recently, evidence has been emerging of the adverse metabolic effects of antidepressants. This study investigated the effects of antidepressants on plasma glucose and other factors in the fat and muscle tissue relating to metabolism. Methods：Long-Evans-Tokushima-Ostuka (LETO) rats were used to evaluate the effects of different antidepressants. Amitriptyline, fluoxetine, and mirtazapine were administered to each of three subgroups for 4 weeks, between 11 and 15 weeks old, while a fourth subgroup was administered no antidepressant during the same period. Changes of weight and daily intake were monitored. Tissues and blood were collected at 15 weeks. Results：The fluoxetine subgroup showed lower weight gain and lower food efficacy ratio than did the other subgroups. Blood glucose and other circulating factors showed no significant differences among groups, except for the leptin levels of the fluoxetine subgroup. However, the amitriptyline and mirtazapine subgroups showed similar patterns in the response of mRNA expression of peroxisome proliferator-activated receptors gamma cofactor-1 and uncoupling protein-1, 2, 3. Conclusion：These results could indicate possible differences in metabolic response based on the kind of antidepressant used.