Electron microscopic observation was carried out on the alterations of finer structures of retina following the daily intraperitoneal injections of BHC (benzenhexachloride) and combination of BHC with copper for 4 weeks and 6 weeks to the rabbit respectively. 1. In both groups, vesicle formation due to sporadic disintegration and elimination of ax-ons in the nerve fiber layer appeared. 2. Formation of large vesicles was noticeable in the cytoplasm of retinal pigment epithelial cells in both 4 weeks and 6 weeks groups which was considered to be a relative enlargement of smooth surfaced endoplasmic reticulum (SER) by the increased enzymatic activities in response to the toxins. Focal thickening of Bruch`s membrane in the group of 4 weeks and focal destruction of the Bruch`s membrane in the group of 6 weeks were observed. 3. Between the BHC inoculated group and BHC combined with copper inoculated group, no conspicuous difference in findings was recognized. More severe alterations of finer retinal structures in the 6 weeks group than in the 4 weeks group were demonstrated.
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