Botulinum toxin 주사후 안검경련증은 완화되었으나 퇴행성의 안검하수와 미모하수 및 피부이완증에 있어 이에 대한 안검성형술을 실시했던 1예에서 절제한 안윤근에서 Botulinum toxin에 의한 병리조직학적 변화를 관찰하였다. 광학현미경 소견상 안윤근이 광범위하게 위축된 소견을 보였으나 신경조직은 손상이 없었으며 염증세포의 침윤도 없었다. 이같은 소견은 Botulinum toxin의 안윤근에 대한 신경근 차단효과에 의해 근육의 마비와 위축이 온 것으로 사료된다(한안지 33 : 719~723, 1992)
A 60-year-old woman who had essential blepharospasm was teated with botulinum toxin A (two injections) around her orbital regions. The patient experienced reduction of blepharospsam for one month. But involutional blepharoptosis, brow ptosis and dermatochalasis had remained, so she underwent blepharoplasty. The resected orbicularis muscle during blepharoplasty was examined histopathologically. It was suggested that nonselective atrophy of the orbicularis muscles was derived from the loss of the normal neurotrophic influence of nerve on muscle by the botulinum toxin A(J Korean Ophthalmol Soc 33 : 719~723, 1992).
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