1987년 7월부터 1988년 9월까지 본원 안과외래를 방문한 안검경련환자 20명과 반측안명경련환자 35명을 대상으로, Scott의 방법에 따라 단안평균 17.81 units의 botulinum toxin을 안검과 미간에 주산한 후 7개월 이상 추적 관찰하였다. 평균연령은 안검경련환자 59세, 반측안명경련환자 49세였고, 남자가 17명(31%), 여자가 38명(69%)으로 여자가 더 많았다. 주사 후 10일 이내에 경련강도와 폐검력은 현저히 감소하였고, 주사 후 1개월경에 경련강도의 최대감소효과가 나타났으며, 평균약효기간은 안검경련환자 159.9일, 반측안면경련환자 167.1일이었다. 주사 후 부작용으로는 토안과 유루증이 가장 많았고, 모두 경미하고 일시적이었으며, 전신적인 부작용은 보이지 않았다.
Twenty cases of blepharospasm and thirty five cases of hemifacial spasm were treated by injection with Botulinum Toxin A during a fifteen-month period. A total of 74 treatment sessions were given for 7 months follow-up period and the mean dose of 17.81 units per lid and brow was administered according to Scott`s mothod. The mean ages of blepharospasm and hemifacial spasm patients were 59 years and 489 years, respectively. The mean response time of toxin against blepharospasm and hemifacial spasm were 159.9 days and 167.1 days respectively. The maxinum effect of texin appeared in the first 1 month period following injection. The mean preinjection spasm grade was +3.17 in blepharospasm, and +2.41 in hemifacial spasm, and mean postinjection spasm grade was +0.88 in blepharospasm and +0.52 in hemifacial spasm. The mean preinjection muscle strength was +3.15 in blepharospasm, and +3.07 in hemifacial spasm, and mean position spasm, and mean postinjection muscle strength was +1.12 in blepharospasm, and +1.24 in hemifacial spasm. The complications attributed to toxin injection were lagophthalmos, and epiphora. These ocular complications were localized, mild and transient, and no systemic side efeects were noted.
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