放射線照射에 依한 肺의 慢性變化에 關한 實驗的 硏究

An Experimental Study on Late Change of the Irradiated Lung

To evaluate late change of irradiated lung, a total of 60 rats was irradiated on right lungfield with a single dose of 2000 rads using Co-60 teletherapy unit. Follow-up roentgenographic and histopathologic study was performed three, six and twelve months after irradiation in each group of 20 rats. The results were as follows: 1. Chest roentgenographic findings in the order of frequency were pneumonic consolidation, atelectasis, and pleural effusion in 3-month follow-up group; atelectasis, fibrostreaky infiltration, and pneumonic consolidation in 6-month follow-up; and normal, and normal, and atelectasis in 12-months follow-up group. 2. Main histopathological findings were alveolar and interstitial exudates, and diffuse infiltration of inflammatory cells in 3-month follow-up group; thickening of interstitium and vascular wall in 6-month follow-up group; and interstitial fibrosis in 12-month follow-up group.