학술저널
Raloxifene, a selective estrogin receptor odulator, induces heme oxygenase-1 expression in RAW264.7 Macrophages
- 강원대학교 기초과학연구소
- 기초과학연구
- 제20집
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2009.12169 - 178 (10 pages)
- 3
Raloxifene. a selective estrogen receptor modulator, is well Known to be a potent anti-inflammatory agent. However, the molecular mechanisms underlying anti-inflammatory action by raloxifene are poorly understood. Here we showed that raloxifene, but not 17-β estradiol, induces expression of heme oxygenase-1 (HO-1), a stress-inducible enzyme with potent anti-inflammatory activity, in murine macrophages and this regulation is independent of estrogen receptor(ER).
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