구강내 편평상피세포암의 방사선치료 후 발생한 악성 흑색종

Radiation-Induced Malignant Melanoma Following Radiation Treatment for Squamous Cell Carcinoma of the Oral Cavity : A Case Report and Review of Literature

구강내에서 발생하는 악성 흑색종은 비교적 드문 종양으로 원인에 대해서는 정확히 알려져 있지는 않으나 방사선치료 후에 발생된 양성 흑색증이 악성으로 전환된 보고가 있다. 본원에서 구강내 편평상피세포암으로 국소방사선치료 후 동일한 부위에 6년 후에 악성 흑색종이 발 생하였기에 문헌고찰과 함께 보고하는 바이다.

Department of Radiation Oncology, Inje University College of Medicine, Seoul, KoreaMalignant melanoma of the oral cavity is rare, accounting for 1 to 8% of all malignant melanomas. The overall prognosis remains poor despite the available treatments such as radical surgery, adjuvant radiotherapy, chemotherapy and immunotherapy due to failure in early detection and tendency in early metastasis. The etiology of mucosal malignant melanoma remains unkown. However, there are few cases of malignant melanoma of the oral cavity reported in the literature, which might be related to preexisting melanosis and radiation treatment. A case with malignant melanoma developed on the same site after 6 years follow ing irradiation for squamous cell carcinoma of the oral cavity is reported in this article.