Phendimetrazine 사용으로 유발된 정신증적 장애 2예

Two Cases of Psychotic Disorder Following Phendimetrazine Use

저자들은 식욕억제제 및 비만치료제로 사용되는 phendimetrazine(펜디라진정, 푸링정)의 복용에 의한 정신증 적 장애 환자 2예를 입원시켜, 약물의 중단 및 소량의 항정신병약물 및 항불안제 투여로 정신증의 소실 및 임상경과의 호전을 경험하였기에 이를 문헌고찰과 함께 보고한다.

Phendimetrazine is a medication currently being used to help patients with weight loss. It shares a chemical structure with amphetamines. As such, it shares some of the same toxicities, which can include psychosis. Two cases present good examples of phendimetrazine-induced psychotic disorder. A 30-year old female was admitted to emergency room with visual hallucination, auditory hallucination and aberrant behavior. Another 38-year old housewife was accompanied by her family to evaluate mood swing, auditory hallucination and behavioral change to psychiatric clinic. After evaluation in psychiatric ward, they were confirmed to have causal relation with prescription diet pills. These case reports demonstrate the potential dangers of amphetamine based diet pills. There have been several cases of cardiomyopathies and pulmonary hypertension related to phendimetrazine, but psychosis is something that is rarely recognized in an outpatient setting. Two cases showed the importance of obtaining a careful medication history in all patients and specially recognizing diet pills with an amphetamine base causing psychosis.