정신분열병 환자에서 생물학적 지표로서 N100, P300과 정량화뇌파의 적용

Application of N100, P300 and QEEG as a Biological Marker in Patients with Schizophrenia

본 연구에서는 정신분열병의 신경생리학적인 이상을 연구하기 위하여 23명의 정신분열병 환자군과 23명의 정상대조 군을 대상으로 사건유발 전위인 P300, N100과 정량화뇌파를 비교하였다. P300의 전위값은 정상대조군보다 정신분열 병 환자군에서 유의하게 낮아졌고 alpha 활성 역시 정신분열병에서 유의하게 감소된 결과를 보여 정신분열병의 생물학적 지표가 될 가능성이 있다. N100 잠복기의 경우에는 정신분열병 환자의 증상 심각도와 상관성이 있었으며, 이는 N100 잠 복기가 정신분열병환자의 증상 심각도를 반영하는 생물학적지표일 가능성을 시사한다.

Objective This study was carried out to investigate the clinical availability of event related potential (ERP) P300, N100 and QEEG as biological markers in schizophrenia (SPR) patients. Methods The 23 SPR patients who met Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) criteria of SPR and age and sex matched 23 normal controls (NC) were recruited. Positive and Negative Syndrome Scale (PANSS) was used to evaluate the clinical symptoms. The three electrodes (Cz, CPz, Pz) were used to measure the amplitude and latency of each ERP components. The qEEG was analyzed by the ranges of Hz: delta (1-3 Hz), theta (4-7 Hz), alpha (8-12 Hz), beta (13-30 Hz) and gamma (30-50 Hz). Results P300 amplitudes of SPR patients were reduced across Cz, CPz and Pz (F=5.81, p<0.05). There was no difference in P300 latency, N100 amplitude and N100 latency between SPR and NC. P300 amplitudes were not influenced by demographic characteristics and PANSS scores in SPR patients. The PANSS positive, negative, general subscale scores were positively correlated with N100 latency at Cz, CPz. SPR patients showed significantly decreased alpha activity (SPR vs. NC= 24.44±6.98% vs. 29.55±6.74%, p<0.05) and increased gamma activity (SPR vs. NC=19.48±5.47% vs. 16.42±4.69%, p<0.05) compared with those of NC. Conclusion The results suggest that the amplitude of P300 and alpha activity can be considered as a biological marker of SPR. And there is a possibility that the latency of N100 may reflect symptom severity of schizophrenia patients.