공황장애 환자에서 기질 및 성격이 약물치료 효과에 미치는 영향

Effect of Temperament and Character on Pharmacotherapy in Panic Disorder Patients

연구자들은 공황장애 환자에서 6개월간의 escitalopram 에 대한 치료 결과와 기질 및 성격 간의 관계에 대해 살펴보 았다. 그 결과 비관해군은 관해군에 비해 기저시점에서 높은RD와 C를 보였으며, 교란변수를 통제했을 때는 기저 시점에 서의 높은 RD 점수만이 좋지 않은 치료 예후와 관련이 있음을 확인하여 RD가 약물치료 효과를 예측할 수 있다는 사실 을 입증하였다. 따라서 향후 공황장애 임상진료에서 기질성격적 특성의 평가가 실제적인 도움이 될 수 있을 것으로 생 각된다.

Objective Temperament and character that represent personality trait are supposed to relate to panic disorder (PD). There are several studies that report a significant relationship among temperament, character and treatment outcome in PD. In this study, we examined whether temperament and character affect the long term outcome of escitalopram treatment in patients with PD. Methods Ninety-two patients with PD were recruited at the psychiatric outpatient clinics of 6 university hospitals in South Korea. All patients were treated with escitalopram for 6 months. The Temperament-Character Inventory-Revised-Short (TCIRS) was administered to all patients at baseline. They were also assessed with the Panic Disorder Severity Scale (PDSS), Hamilton Rating Scale for Anxiety (HAM-A), 17-item Hamilton Rating Scale for Depression (HAMD-17), and Clinical Global Impression on-Severity (CGI-S) at both baseline and after 6 months of pharmacotherapy. Results There was a significant relationship between reward dependence (RD) and a remission rate in PD patients who were treated with escitalopram, and panic patients who had high RD showed a low remission rate after the treatment. Conclusion This study suggests that high RD predicts a poor treatment response in patients with PD.