정신과 급성기 입원 환자에서 비정형 항정신병약물의 중단율 비교

Comparison of Atypical Antipsychotics Discontinuation Rate in Acute Phase Hospitalized Patients-Retrospective Chart Review Study

본 연구의 목적은 정신분열병 또는 양극성장애 조증 삽화등의 급성기 입원 환자를 치료할 때 비정형 항정신병약물들 의 중단율을 비교하는 것이다. 2007년 1월부터 2008년 12월까지 2개의 대학병원 정신과 병동에 입원한 환자들의 의무 기록을 후향적으로 조사하였으며 olanzapine, risperidone,aripiparzole을 처방 받은 환자들을 선별하여 각 환자군 (olanzapine,risperidone, aripiparzole)들의 항정신병약물의 중단율과 치료유지 기간을 비교하였다. 환자군들 사이의 중단율은 통계적으로 유의한 차이가 없었고 치료중단의 예측인자는 짧은 적정기간과 긴 유병기간이었다.

ObjectiveThe purpose of this study was to compare the discontinuation rate of widely prescribed atypical antipsychotics when administered to newly admitted, acutely ill patients with schizophrenia or bipolar mania. MethodsMedical records of patients admitted to psychiatric ward of two university hospitals between January 2007 and December 2008 were retrospectively reviewed. Subjects were eligible for inclusion if they prescribed olanzapine, risperidone or aripiprazole for their psychotic or manic symptom control. Patient groups (olanzapine/risperidone/aripiprazole) were compared for rate of antipsychotics discontinuation and duration of treatment continuation. ResultsThere was no statistically significant difference in the rates of discontinuation during hospitalized period between olanzapine, risperidone and aripiprazole. Rates of discontinuation were 14.5% for olanzapine, 18.6% for aripiprazole and 24.0% for risperidone. Predictor of treatment discontinuation was short titration period and long illness duration. ConclusionThis study demonstrated that risperidone, olanzapine and aripiprazole were comparable with no difference found on the discontinuation rate in treating acutely ill psychiatric patients. However, the small number of patients who participated in this study made it difficult to establish significance.