녹차, 청차 및 홍차 투여에 의한 당뇨쥐의 혈당과 콜레스테롤 함량 변화

Effects of Camellia sinensis L. on Blood Glucose and Cholesterol Levels of Normal and Streptozotocin Induced Diabetic Male Rats

This study was designed to examine the effects of ethanol extract of green tea (non-fermented tea, GT), chung tea (10% fermented tea, CT) and black tea (fermented tea, BT) on blood profiles in normal and diabetic rats. Rats were divided into normal [normal-control (NC), GT (N-GT), CT (N-CT), and BT (N-BT)] and diabetic groups [diabetic-control (DC), diabetic-GT(D-GT), diabetic-CT (D-CT), and diabetic-BT (D-BT)]. Diabetic groups (DC, D-GT, D-CT, and D-BT) were induced to have diabetes mellitus by streptozotocin (STZ) injection (45 mg/kg body weight) into the tail vein. Normal groups (NC, N-GT, N-CT, and N-BT) were injected with citrate buffer alone. No significant changes in plasma glucose were shown in normal rats regardless of administration of GT, CT, and BT. Significant decreases in plasma glucose were shown in the diabetic groups, D-GT, D-CT, and D-BT. Plasma cholesterol levels were significantly lower in the D-GT and D-BT groups compared to the DC group. D-CT and D-BT demonstrated decreased ALT activity. In conclusion, Camellia sinensis L. might be effective for the treatment of diabetes by reducing blood glucose, cholesterol, and ALT levels in STZ-induced diabetic male rats.