중심 측두엽 극파 동반 양성 간질에서의 인지 행동 관찰 및 topiramate 1일 1회 투약효과

Cognitive and Behavioral Problems and the Effectiveness of Topiramate Once per Day in the Control of Benign Childhood Epilepsy with Centrotemporal Spikes

Purpose : This study was aimed to evaluate cognitive and behavioral problems in benign childhood epilepsy with centrotemporal spikes (BECTS) using objective scales. In addition, we investigated the efficacy and cognitive effects of topiramate by intro- ducing it once a day as a pilot study. Methods : Seven patients were evaluated. They were diagnosed as BECTS based on clinical features and electroencephalography findings. We assessed cognitive and behavioral functions with several neuropsychological tests and followed up the sei- zure frequency, side effects, and cognitive dysfunction for six months after intro- ducing topiramate once per day. Results : The mean intelligence quotient, memory quotient, and social quotient of patients show the difference as compared to the general population. However, three patients showed attention deficit/hyperactivity disorder. Further, the seizure reduc- tion rate was 100% after receiving topiramate once a day and there were no newly reported neuropsychological problems on questionnaires. Conclusion : This study demonstrated that a significant number of children with BECTS have behavioral problems and that topiramate monotherapy once a day is effective.