신생아 뇌졸중의 임상적 양상에 관한 연구

Clinical Spectrum of Neonatal Strokes

Purpose : Neonatal strokes are common and may be associated with various com- plications. However, few studies have been conducted on the clinical spectrum in Korea. This study aimed at investigating the clinical presentation and neurological outcome of neonatal strokes. Methods : Twenty-seven neonates with neonatal stroke were enrolled in the neo- natal intensive care unit at Kyungpook National University Hospital from January 2000 to December 2009. Their medical records and neuroradiological findings were retrospectively reviewed. Results : The mean age of the subjects was 4 5.6 days. Sixteen patients were full ± term, nine were prematurite and six had low birth weights. The onset of symptoms was mostly within first week (85.2%) of life, especially in the first day of life (51.9 %). The most common symptom was seizure (40.7%), which were focal clonic (38.5 %) or multifocal clonic (38.5%). Nine patients showed abnormal EEG findings. Thirteen patients had subdural hemorrhage, seven showed intraventricular hemor- rhage, and three revealed cerebral infarction. Among 12 patients who followed-up for one year, four had mild neurologic dysfunction and two had severe impairment. Conclusion : We found that the onset of symptom in neonatal strokes was mostly within the first day of life, and the most common symptom was focal seizure. We, therefore recommend that neuroimaging be done when newborns have seizures within their first week of life. However, further studies are needed to elucidate this further.