지역사회 경도인지장애 노인군에서 Apolipoprotein E ε4와 지질농도가 인지기능에 미치는 영향

The Influence of Apolipoprotein E ε4 and Lipid Profile on Cognitive Function in Community-Dwelling Elders with Mild Cognitive Impairment

본 연구는 지역사회 경도인지장애 노인군에서 APOE ε4 여부에 따른 지질 양상들과 인지기능 평가 점수 사이의 관계를 알아보기 위해 수행되었다. 인지기능 평가에 한국판 세라드 신경심리검사가 이용되었고 총콜레스테롤, 중성지방, 고밀도지단백콜레스테롤, 저밀도지단백콜레스테롤 농도가 지질 양상에 포함되었다. 평가 결과 APOE ε4를 가진 경도인지장애 노인군에서 고밀도지단백콜레롤 농도와 한국판 세라드 신경심리검사항목인 단어목록회상검사 점수 사이에 유의한 상관관계를 보였다. 결론적으로 지역사회 경도인지장애 노인군에서 APOE ε4가 있을 경우에 고밀도지단백콜레스테롤 혈중농도가 신경심리검사의 언어적 삽화기억 영역과 상호 연관될 수도 있을 것이다.

Objective The aim of this study is to examine the relationship between lipid profiles including total cholesterol (TC), triglyseride (TG), high-density lipoprotein cholesterol (HDL-cholesterol), and low-density lipoprotein cholesterol (LDL-cholesterol) and cognitive function by the occurrence of the apolipoprotein E (APOE) ε4 in the community-dwelling elderly individuals with mild cognitive impairment (MCI). Methods The total number of subjects was 203 (77 men and 126 women) who were diagnosed with MCI from a Korean project of Early Detection of Dementia . Aged 65-85 years were included in this analysis. The eight neuropsychological domain from the Korean version of Consortium to Establish a Registry of Alzheimer’s Disease neuropsychological test battery (CERAD-K, NP) were conducted to test subjects. The lipid profiles of all subjects were measured including TC, TG, HDL-cholesterol, and LDL-cholesterol levels and the correlation between the lipid levels and the neuropsychological test scores was analyzed by the occurrence of the APOE ε4. Results There was significant correlation between HDL-C and Word List Recall Test (WLRT) of the neuropsychological test score in CERAD-K (NP) in the presence of APOE ε4 (WLRT/HDL-C: r=0.163, p<0.05). Conclusion The HDL-C level might be correlated with verbal episodic memory domain in CERAD-K (NP) test in the presence of APOE ε4 in community-dwelling elders diagnosed with MCI.