일반적 의학적 상태로 인한 섬망

Delirium due to General Medical Condition

Delirium is the most common psychiatric syndrome found in the hospital setting and a common cause of mortality and morbidity in physically ill patients, but clinician often do not recognize when their patients are delirious. The main pathophysiology of delirium is biochemical alterations in CNS such as cholinergic, dopaminergic, serotonergic, noradrenergic, glutamatergic and GABAergic dysfunction. However, various processes of inflammatory response, physiologic stress, oxidative failure, dehydration and electrolyte imbalance can influence brain chemistry and functioning in delirium due to general medical conditions such as cardiovascular disease, pulmonary disease, hip fracture, infectious disease, liver disease, renal disease and advanced cancer. If we get to understand the pathogenesis that result disordered brain function that cause delirium, we will be able to find more specific and tailored treatment tools of this complex syndrome.