아포지단백(Apolipoprotein) ε4 유전자형과 치매환자의 인지기능, 일상생활기능 및 행동증상

Apolipoprotein ε4 and Cognitive Function, Daily Living Ability and Behavioral Symptoms of Dementia

Objectives：We investigated the relationship between apolipoprotein ε4 and clinical features of dementia. Methods：Samples were obtained from 33 dementia patients in Korea, Buyeo Geriatric Hospital and apolipoprotein E polymorphisms were analysed using polymerase chain reaction and restriction fragment length polymorphism. The multidimensional evaluating methods (MMSE-K, B-ADL, BEHAVE-AD, GDS, GMHR) for dementia were performed to analyze relationship with Apolipoprotein E genotypes. Results：The distributions of the apolipoprotein E genotypes of the dementia patients were presented by ε3/ε3 (58%), ε3/ε4 (22%), ε2/ε3 (15%), and ε4/ε4 (0%). There is no significant relationship between apolipoprotein ε4 and the findings of multidimensional evaluating measures. Conclusion：We could not find the association between apolipoprotein ε4 and the scores of the multidimensional evaluating measures of dementia patients. The results suggested that apolipoprotein ε4 might not play a main role in cognitive function, daily living ability and behavioral symptoms of dementia.