정신분열병 여성환자에서 항정신병 약물로 인한 무월경이 치료에 대한 환자의 태도와 삶의 질에 미치는 영향

Effects of Antipsychotics-Induced Amenorrhea on Attitudes Toward Treatment and Quality of Life in Women with Schizophrenia

본 연구는 여자 정신분열병 환자들에서 무월경의 여부에 따른 치료에 대한 태도와 삶의 질의 연관성에 대해 알아보고 자 하였다. 그 결과 무월경군이 대조군에 비해 치료에 대한 환자의 태도에 있어서 통계학적으로 유의한 상관관계를 보이지 않았지만, 무월경군은 삶의 질 중, 사회적 관계 영역이 대조군에 비해 저하되는 소견을 보였다. 이것은 무월경 자체가 정신분열병 환자들의 삶의 질 중 일부영역을 저하시킬 수 있다는 것을 시사한다. 치료자들은 정신분열병의 약물치료에 있어 빈번하게 나타나는 무월경을 쉽게 간과해서는 안 될 것이고, 치료에 대한 태도 및 삶의 질에 대한 다른 요인들을 파악하고 교정함으로써 치료 효과의 증대와 더불어 환자의 치료에 대한 순응도를 높일 수 있을 것이다.

Objective This study was aimed to identify the correlation between antipsychotics-induced amenorrhea, and attitudes toward treatment and quality of life in women with schizophrenia. Methods Twenty female schizophrenic patients with antipsychotics-induced amenorrhea and thirty female schizophrenic patients without antipsychotics-induced amenorrhea were evaluated. Attitudes toward treatment were assessed by the Korean version of Drug Attitude Inventory (KDAI-10) and quality of life was assessed by the Korean version of World Health Organization Quality of Life Assessment Instrument-BREF (WHOQOL-BREF). The psychopathology of each patient was assessed by the Positive and Negative Syndrome Scales and the Clinical Global Impression-Severity. Adverse effects were evaluated using the Drug-Induced Extrapyramidal Symptoms Scale. Correlation analysis and multiple linear regression were conducted. Results The KDAI-10 score was not significantly correlated antipsychotics-induced amenorrhea. In WHOQOL-BREF score, social relation domain only showed significant correlation with antipsychotics-induced amenorrhea. Multiple linear regression analysis revealed that the number of family members contributed significantly to the Positive Subjective Feelings Scores of KDAI-10 and marital status contributed significantly to the social relation domain of WHOQOL-BREF in amenorrhea group. Conclusion The results of present study suggest that antipsychotics-induced amenorrhea lower part of the quality of life domain in women with schizophrenia. Clinicians must pay attention to treatment of amenorrhea and various factors that correlated with attitudes toward treatment and quality of life in women with schizophrenia.