여주(Momordica charantia.) 추출물이 고지방식이를 급여한 C57/BL6J 생쥐의 체중변화 빛 혈중지질에 미치는 영향

Effects of Bitter melon (Momordica charantia.) extracts on Body weight change and lipid composition in C57/BL6J Mice Fed High Fat Diet

This study was conducted to investigate the effects of Bitter melon(Momorica charantia L.) extracts on anti-obesity and lipid profiles in C57IBL6J mice fed high fat diet. Mice were fed normal diet (NFD. normal control). and high-fat diet only (HFD. high fat control) and high-fat with bitter melon extract 5% (5% BHD). high-fat with bitter melon extract 10% (10% BHD) for 6 weeks. Body weight gains were significantly lower in the experimental groups. and FER was significantly lower in the experimental groups in a dose-dependent manner than HFD (p(0.05). Liver weight in 5% BHD was significantly lower and kidney weight is significantly lower in the experimental groups. Not only Adipose tissue weight but also body fat percentage was significantly lower in the experimental groups. The serum TG levels were decreased in the experimental groups and TC levels were significantly lower in the experimental groups in a dose-dependent manner than HFD (p(0.05). LDL-C levels were decreased in the 10% BMD. However, blood glucose levels were not significantly different among the groups. From the findings, it had shown that bitter melon extract have the anti-obesity effect and could improve lipid profiles.